Aktivitas Antibakteri Ekstrak Goji Berry untuk Menghambat Bakteri Propionibacterium Acnes Penyebab Acne Vulgaris

Antibacterial Activity of Goji Berry Extract to Inhibit Propionibacterium Acnes Bacteria Causing Acne Vulgaris

Abstract

Background: Propionibacterium acnes is a Gram-positive bacterium that acts as a normal flora and body pathogen that causes acne vulgaris. Treatment using natural ingredients is an alternative that can be used to cure disease, one of the medicinal plants that has benefits is Goji berry (Lycium barbarum L).  Objective: The aim of this research was to determine the anti acne activity of goji berry extract in inhibiting the growth of P.acnes bacteria and screening phytochemical compounds in goji berry extract. Methods: This quantitative study uses goji berry extract with 96% ethanol solvent obtained by maceration and evaporation methods. The data were statistically analyzed to see a significant effect using One Way Anova. Goji berry extract with varying concentrations (20%, 40%, 60%, 80%, and 100%) was used in the antibacterial activity test for Propionibacterium acnes using the well diffusion method on MHA media. Phytochemical screening was carried out by testing for the presence of flavonoid compounds, tannins, saponins, triterpenoids, alkaloids, steroids, and glycosides. Results: Goji berry extract showed antibacterial activity against P. acnes with moderate inhibitory ability at 100% concentration with an inhibitory zone diameter of 7 mm. Meanwhile, at concentrations of 20%, 40%, 60%, and 80%, the diameter of the inhibition zone is 4,05 mm; 4,46 mm; 4,53 mm and 5,19 mm respectively with low inhibition capability. The results of the phytochemical screening tests showed a positive content of flavonoid compounds, saponins, tannins, triterpenoids, and glycosides. Conclusion: This compound is known to have the ability to inhibit and even kill bacteria with different mechanisms in each compound.