Synthesis And Antibacterial Activities Test Of Chalcone (E)-3-(4-(Dimethylamino)Phenyl)-1-Phenylprop-2-En-1-One Against Bacteria Contaminant Blood Products
Abstract
Chalcone compounds and their derivatives are known to have various pharmacological activities, one of which is antibacterial activity. This activity is strongly influenced by the type of bound substituent and the location of the substituent on the structure of the chalcone compound. The purpose of this study was to synthesize chalcone compounds with the characteristics of the dimethylamino substituent on ring B at the para ((E)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one) position and to test the activity of an antibacterial compound of chalcone against bacterial isolates of blood product contaminants. Antibacterial activity testing was focused on bacterial isolates derived from blood products, because the use of blood product bacterial isolates for antibacterial testing was still not widely used, generally the test bacteria used were ATCC bacterial isolates. The antibacterial activity test method used was the paper disc diffusion method, the antibacterial activity of chalcone compounds was known through the formation of a clear zone around the disc paper called the inhibition zone for bacterial growth. The chalcone compound (E)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one was successfully synthesized through a condensation reaction, which obtained a yellow crystalline solid with a yield of 81.67%. The results of the activity test of chalcone compounds on several blood product contaminants showed that this compound had good enough activity in inhibiting the growth of Staphylococcus aureus bacteria with an inhibition zone of 8.9 mm at a concentration of 25 ppm.
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References
Cabrera, M., Simoens, M., Falchi, G., and Lavaggi, M.L., (2007), Synthesis Chalcones, Flavanones and Flavones as Antitumoral Agents: Biological Evaluation and Structure-Activity Relationships, Bioorg. Med. Chem, Vol. 15, Halaman 3356-3367
Castro, C.C.B., Costa. P.S., Laktin, G.T., Carvalho, P.H.D., and Geraldo, R.B., (2015), Cardamonin, A Schistosomicidal Chalcone from Piper Aduncum L. (Piperaceae) that Inhibits Schistosoma Mansoni ATP Disphosphohydrolase, Eur. J. Med Chem, Vol. 22, Halaman 921-928
Dan, W. dan Dai, J., (2020), Recent developments of chalcones as potential antibacterial agents in medicinal chemistry, European Journal of Medicinal Chemistry, Vol. 187, Halaman 1-20
Rashid H., Xu Y.M., Ahmad N., Muhammad Y., dan Wang L.S., (2019), Promising antiinflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor kb activities, Bioorg. Chem, Vol. 87, Halaman 335-365
Kusumaningrum, S.B.C dan Sepvianti, W., (2020), Identifikasi Bakteri Kontaminan Pada Produk Darah Thrombocyte Concentrate, Syifa’ MEDIKA, No. 2, Vol. 10, Halaman 117-123 DOI: https://doi.org/10.32502/sm.v10i2.2185
Newman, D.J., dan Cragg, G.M., (2016), Natural products as sources of new drugs from 1981 to 2014, J. Nat. Prod, Vol. 79, Halaman 629-661
Rasyidah, (2014), Pola Kuman dan Uji Kepekaan Antibiotik pada Sepsis Neonatum di Unit Perawatan Neonatis RSUD dr Pirngadi Kota Medan, Sari Pediatri, Vol. 15, Halaman 341-344
Rossiter, S.E., Fletcher, M.H., dan Wuest, W.M., (2017), Natural products as platforms to overcome antibiotic resistance, Chem. Rev, Vol. 117, Halaman 12415-12474
Sepvianti, W, (2016), Sintesis dan Uji Sitotoksisitas Turunan Kalkon terhadap Sel Kanker T47D, Hela dan WiDr secara In Vitro, Tesis, Program Pasca Sarjana Ilmu Kimia, Universitas Gadjah Mada
Sepvianti, W dan Kusumaningrum, S.B.C., (2019), Antibacterial Assay of 2’-Hydroxy-4’,6’,4-Trimethoxychalcone and 4-Methoxychalcone Against Gram Positive and Gram Negative Bacteria, Jurnal Riset Kesehatan, No. 2, Vol. 8, Halaman 17 – 20. DOI: https://doi.org/10.31983/jrk.v8i2.5378
Syahril, J., Yuanita, E., Nurohmah, B.A., Armunanto, R., dan Purwono, B., (2017), Chalcone analogue as potent anti-malarial compounds against Plasmodium falciparum: Synthesis, biological evaluation, and docking simulation study, Asian J Trop Biomed, No. 8, Vol. 7, Halaman 675-679
Tjiptoprajitno, N.A., Aryanti, Sudiana, I.K., (2012), Analisis Produk Darah Thrombocyte Concentrate di Palang Merah Indonesia Surabaya, Jurnal Biosains, Vol. 14,Halaman 145-152
Wright, G.D., (2017), Opportunities for natural products in 21st century antibiotic discovery, Nat. Prod. Rep, Vol. 34, Halaman 694-701
Zhuang, C.L., W. Zhang, C.Q. Sheng, W.N. Zhang, C.G. Xing, Z.Y. Miao., (2017), Chalcone: a privileged structure in medicinal chemistry, Chem. Rev, Vol. 117, Halaman 7762-7810
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