Trygliceride and Total Cholesterol level as the predictor of mortality in stroke patient: Literature Review
Abstract
Stroke is the leading cause of morbidity and mortality worldwide, who rank in 3rd after heart disease and cancer. Data based on the results of Riskesdas 2018 the prevalence of stroke is 10.9% and 15.4% of stroke case caused Indonesia. The province with the 3rd highest incidence is South Kalimantan at 12.7% per mil. Hypertriglyceridemia and hypercholesterolemia are risk factors for ischemic stroke. Low triglyceride and total cholesterol levels contribute to intracerebral haemorrhage. This study to analyse the relationship of laboratory results triglycerides and total cholesterol to mortality in stroke patients. Method: Study are used literature review, searching online journals and sources from databases. Using keywords, namely stroke mortality, total cholesterol, and triglycerides. Results of the literature review, it was found that there were 18 journals were analysed that triglycerides and total cholesterol predictors of prognosis and mortality in stroke patients. Range of values affect is high triglyceride levels > 200 mg/dL and high total cholesterol levels >160-240 mg/dL affect the formation of atherosclerosis effect on blood vessel blockage occurs in ischemic stroke patients. Low triglyceride levels <150 mg/dL and low cholesterol <120-180 mg/dL causes malnutrition which can worse in stroke patients. Low levels of triglycerides and cholesterol effect on the integrity of cell membranes and resistance to rupture, resulting in prolonged bleeding. From this analysis it can be concluded that high or low levels of triglycerides and total cholesterol had effect on prognosis and mortality in stroke patients based on the pathophysiology that occurs.
Downloads
References
Aini, A. Q., Pujarini, L. A., & Nirlawati, D. D. (2017). Perbedaan Kadar Kolesterol Total Antara Penderita Stroke Iskemik dan Stroke Hemoragik. Biomedika, 8(2). 1–5.
Alrabghi, L., Alnemari, R., Aloteebi, R., dkk. (2018). Stroke types and management. International Journal Of Community Medicine and Public Health. 5(9). 3715.
American, A. H. (2021). 2021 Heart Disease and Stroke Statistics Update Fact Sheet American Heart Association Research Heart Disease, Stroke and other Cardiovascular Diseases Coronary Heart Disease (CHD). Retreived From: https://www.heart.org/-/media/phd-files-2/science-news/2/2021-heart-and-strokestatupdate/2021_heart_disease_and_stroke_statistics_update_fact_sheet_at_a_glance.pdf
American Heart Association. (2020). 2020 Heart Disease & Stroke Statistical Update Fact Sheet Global Burden of Disease High Blood Cholesterol and Other Lipids. (Cvd), 9–11. Retreived From: https://professional.heart.org/-/media/phd-files-2/science-news/2/2020-heart-and-stroke-statupdate/2020_heart_disease_and_stroke_statistical_update_fact_sheet_blacks_and-cvd_ucm505477.pdf?la=en
Andaryani, N. W. R. N. (2017). Rasio Kadar Trigliserida-Kolesterol HDL Serum Tinggi Meningkatkan Keparahan Klinis Penderita Stroke Iskemik Akut. MediChina. 48(3). 211–215.
Ariswanda, I. G. A. G., Adnyana, I. M. O., Widyadharma, I. P. E., dkk. (2020). Low Total Cholesterol Serum Levels As A Poor Outcome Predictor For Intra-Cerebral Hemorrhage Stroke. MNJ (Malang Neurology Journal). 6(2). 69–72.
Chen, L., Xu, J., Sun, H., dkk. (2016). The Total Cholesterol To High-Density Lipoprotein Cholesterol as a Predictor of Poor Outcomes in a Chinese Population with Acute Ischaemic Stroke. Journal of Clinical Laboratory Analysis, 31(6). 1–6.
Chen, Y., Li, C., Yang, C., dkk. (2017). Low Cholesterol Level Associated with Severity and Outcome of SpontaneousIntracerebral Hemorrhage: Results from Taiwan Stroke Registry. 12(4). 1–15.
Deng, Q.-W., Wang, H., Sun, C.-Z., dkk. (2016). Triglyceride to High-Density Lipoprotein Cholesterol Ratio Predicts Worse Outcomes After Acute Ischaemic Stroke. European Journal of Neurology. 24(2). 283–291.
Deng, Qi-wen, Li, S., Wang, H., Zuo, L., Zhang, H., Gu, Z., & Yan, F. (2018). The Short-term Prognostic Value of the Triglyceride-to- high-density Lipoprotein Cholesterol Ratio in Acute Ischemic Stroke. 9(3). 498–506.
Deng, Qiwen, Li, S., Zhang, H., Wang, H., dkk. (2018). Association of Serum Lipids with Clinical Outcome in Acute Ischaemic Stroke: A Systematic Review and Meta-Analysis. Journal of Clinical Neuroscience. 59. 236-244.
Gaghauna, E. E., & Santoso, B. R. (2019). The Effect of Self Efficacy Towards Independency Level of Post-Stroke Patient in General Hospital Neuro Policlinic Ulin Banjarmasin. Journal Of Nursing Practice, 2(2), 130-135.
Gaghauna, E. E., Santoso, B. R., & Alfian Muhammad (2020). Pengaruh Family Health Seek Behavior Terhadap Outcome Pasien Stroke dengan Menggunakan National Institute Of Health Stroke Scale (NIHSS) di Ruang IGD. Dinamika Kesehatan jurnal kebidana dan keperawatan, 11(2), 593-604.
Jamini, T., Yunita., Yulyanti., (2020). Jurnal Kesehatan Indonesia (The Indonesian Journal of Health), Vol. X, No. 3, Juli 2020. XI(3), 128–132.
Johnson, W., Onuma, O., Owolabi, M., dkk. (2016). Stroke: a Global Response is Needed. Bulletin of The World Health Organization. 94(9). 634-634.
Kemenkes, R. (2019). Infodantin Stroke Kemenkes Ri 2019. Infodantin Stroke Kemenkes RI 2019. Retreived From: https://pusdatin.kemkes.go.id/article/view/20031000003/infodatin-stroke.html
Kim, M. K., Han, K., Kim, H., dkk. (2017). Cholesterol Variability and The Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Study. European Heart Journal. 38(48). 3560–3566.
Laufs, U., Parhofer, K. G., Ginsberg, H. N., dkk. (2020). Clinical Review on Triglycerides. European Heart Journal. 41(1). 99–109.
Lee, H., Park, J., Hwang, I., dkk. (2020). Association of Four Lipid Components with Mortality, Myocardial Infarction, ¨ Ve Young Adults: and Stroke in Statin-Naı A Nationwide Cohort Study. 27(8). 870-881.
Lee, M. J., Park, J. T., Han, S. H., dkk. (2017). The Atherogenic Index of Plasma and the Risk of Mortality in Incident Dialysis Patients: Results from Nationwide Prospective Cohort In Korea. PloS one, 12(5).
Li, Z., Zhang, J., & Luo, Y. (2020). Impact of Triglyceride Playing on Stroke Severity Correlated to Bilirubin. 99(36). 1-5.
Liu, Q., Zhao, W., Xing, Y., dkk. (2020). Low Triglyceride Levels are Associated with Unfavorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage. Neurocritical Care. 34(1). 218-226
Maulida, M., Mayasari, D., & Rahmayani, F. (2018). Pengaruh Rasio Kolesterol Total terhadap High Density Lipoprotein ( HDL ) pada Kejadian Stroke Iskemik. Majority. 7(21). 214–218.
Niu, L., Jiang, S., Wang, Y., dkk. (2020). Total Cholesterol Affects the Outcome of Patients with Anterior Cerebral Artery-Occluded Acute Ischemic Stroke Treated with Thrombolysis. 24(3). 1504–1514.
Pratiwi, L. N., & Andina, M. (2018). Perbedaan Kadar Trigliserida dan Kadar Kolesterol Total pada Penderita Stroke Iskemik Baru dengan Rekuren di Rumah Sakit Umum Haji Medan Provinsi Sumatera Utara Tahun 2015-2016. Anatomica Medical Journal. 1(2). 66.
Sacks, F. M., Lichtenstein, A. H., Wu, J. H. Y., dkk. (2017). Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Circulation. 136(3). e1–e23.
Siregar, F. A., & Makmur, T. (2020). Metabolisme Lipid Dalam Tubuh. Jurnal Inovasi Kesehatan Masyarakt. 1(2). 60–66.
Tziomalos, K., Giampatzis, V., Bouziana, S. D., dkk. (2016). Prognostic significance of major lipids in patients with acute ischemic stroke. Metabolic Brain Disease. 32(2). 395-400.
Wang, I.-K., Liu, C., Yen, T., Jeng, J., dkk. (2017). Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients. Journal of Stroke and Cerebrovascular Diseases. 26(6). 1349–1356.
Wang, I., Liu, C., Yen, T., dkk. (2018) Lower Fasting Serum Triglyceride Levels on Admission are Associated with Increased Risks of 30-Day and 1-Year Mortality in Patients with Ischemic. Stroke Angiology: Open Access. 6(2). 1–7.
Wang, H. H., Garruti, G., Liu, M., dkk. (2017). Cholesterol and Lipoprotein Metabolism and Atherosclerosis: Recent Advances in Reverse Cholesterol Transport. Annals of Hepatology. 16. S27–S42.
Yaghi, S., & Elkind, M. S. V. (2015). Lipids and Cerebrovascular Disease. Stroke. 46(11). 3322–3328.
Yi, S.-W., Shin, D., Kim, H., Yi, J., & Ohrr, H. (2017). Total Cholesterol and Stroke Mortality in Middle-Aged and Elderly Adults: A Prospective Cohort Study. Atherosclerosis. 270. 211–217.
Yuziani, Y. (2018). Korelasi Rasio Kolesterol Total Terhadap HDL dengan Prediksi Outcome Stroke Iskemik Akut. Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya. 2(01). 59–71.
Zhang, A., Yao, Y., Xue, Z., dkk. (2018). A Study on the Factors Influencing Triglyceride Levels among Adults in Northeast China. Scientific Reports. 8(1). 6388.
Copyright (c) 2023 Bagus Rahmat Santoso, Eirene E.M. Gaghauna, Raihana Raihana
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY), that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).